U.S. President Donald Trump addressed the attack in Manchester during his joint press conference with Palestinian President Mahmoud Abbas in the West Bank city of Bethlehem on Tuesday morning.
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Speaking alongside Abbas, Trump condemned the "evil losers" behind the attack. "I won't call terrorists monsters, they would like that name. I will call them losers, because that's what they are," Trump said.
At least 22 people were killed and more than 59 were wounded in the suicide bombing, which took place at an Ariana Grande concert in Manchester on Monday night. Local officials said children were among the attack victims.
According to British police, the attack was carried out by one man who died at the arena after detonating a device he was carrying. Authorities are still unsure whether the man acted alone.
Prime Minister Benjamin Netanyahu strongly condemned the blast, which he described as "a terrible terror attack," and sent his condolences to the families of the victims.
"Terrorism is a worldwide threat and the enlightened nations must work together to defeat it everywhere," Netanyahu said.
Britain is on its second-highest alert level of "severe," meaning an attack by militants is considered highly likely.
Five hours after the attack, Grande tweeted that she was "broken. from the bottom of my heart, i am so so sorry. i don't have words."
Monday night's attack was the biggest in Britain since the July 2005 bombings in London, when a string of suicide bombings left 52 people dead and another 700 wounded.
The blast also came two and half weeks ahead of an election in which May is predicted by opinion polls to win a large majority.