British Prime Minister Theresa May is expected on Friday to announce her departure from office, The New York Times reported, without citing a source.
May will remain as prime minister while her successor is elected in a two-stage process under which two final candidates face a ballot of 125,000 Conservative Party members, the newspaper said.
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Her last gambit, offering the prospect of a possible second referendum and closer trading arrangements with the EU, triggered a revolt by some Brexit-supporting ministers including the resignation of Andrea Leadsom on Wednesday.
The BBC said more ministers could resign.
"I no longer believe that our approach will deliver on the referendum result," Leadsom, once a challenger to May to become prime minister, said in a resignation letter.
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"I have heard very clearly the mood of the parliamentary party," May said. "I know there is a desire for a new approach - and new leadership - in the second phase of the Brexit negotiations - and I won't stand in the way of that."
May had already promised to step down before the next election, due in 2022.