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The Las Vegas Review-Journal's editorial board said it made the decision after meeting with several GOP candidates – not including frontrunner Donald Trump, who couldn't work an interview into his schedule.
The editorial stated that Adelson wasn't involved in the decision to endorse Rubio.
“The Adelsons have detached themselves from our endorsement process, and our endorsement of Sen. Rubio does not represent the support of the family," the editorial said.
It was reported earlier this week that the billionaire and his wife, Miriam Adelson, individually gave the maximum permitted direct personal donation to Ted Cruz's campaign last quarter - $2,700 each, a clue to where their preferences lie. However, it was also reported that Adelson’s first choice for the GOP presidential nomination is Rubio while his wife prefers Cruz.
The newspaper said it chose to endorse the 44-year-old Florida senator for his connection to Nevada, his positions on federal land ownership, immigration and Medicare, as well as his electability.
The Nevada Republican caucuses are set to take place on February 23.
Adelson purchased the Las Vegas Review-Journal, Nevada's largest newspaper, for $140 million in early December, and went to unusual lengths to keep the fact he was the new owner under wraps.