Israel and Hamas have agreed to a 72-hour humanitarian cease-fire to start Friday, though Secretary of State John Kerry cautioned there were "no guarantees" the lull in violence would bring an end to the 24-day-old Gaza war.
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The announcement came hours after Israeli Prime Minister Benjamin Netanyahu vowed to destroy Hamas' tunnel network "with or without a cease-fire" and as the Palestinian death toll soared past 1,400.
Noting the difficulties that lay ahead, Kerry said: "This is not a time for congratulations or joy or anything except a serious determination — a focus by everybody to try to figure out the road ahead," Kerry said. "This is a respite. It is a moment of opportunity, not an end."
At least four short humanitarian cease-fires have been announced since the conflict began, but each has been broken by renewed fighting.
A joint statement released simultaneously in New Delhi, where Kerry is traveling, and at UN headquarters in New York, said the U.S. and UN had gotten assurances that all parties to the conflict had agreed to an unconditional cease-fire.
Hamas, the dominant militant group in the Gaza Strip, said it would abide by a three-day mutual ceasefire with Israel to begin early on Friday.
"Acknowledging a call by the United Nations and in consideration of the situation of our people, resistance factions agreed to a 72-hour humanitarian and mutual calm that begins at 8 a.m (0500 GMT) on Friday as long as the other side abides by it," Hamas spokesman Sami Abu Zuhri told Reuters.
"All the Palestinian factions are united behind the issue in this regard," Abu Zuhri said.
An official at the prime minister's office confirmed that Israel had agreed to a 72-hour truce beginning at 8 a.m. local time Friday.
Israeli and Palestinian delegations were expected to travel immediately to Cairo for talks with the Egyptian government aimed at reaching an end to the conflict.
"It is up to the parties — all of them — to take advantage of this moment," Kerry said. "There are no guarantees. This is a difficult, complicated issue."
During the cease-fire, Kerry said Israel will be able to continue its defense operations to destroy tunnels that are behind its territorial lines. The Palestinians will be able to receive food, medicine and humanitarian assistance, bury their dead, treat the wounded and travel to their homes. The time also will be used to make repairs to water and energy systems.
"We hope this moment can be grabbed by both parties, but no one can force them to do that," Kerry said.
"Israel has to live without terror and tunnels and rockets and sirens going on through the day," he said. "Palestinians have to be able to live freely and share in the rest of the world and live a life that is different from the one they have long suffered."
The Palestinian delegation is expected to include members of Hamas, which the United States and Israel consider a terrorist organization and cannot be negotiated with directly. So if the Israelis and Palestinians meet face to face, the Hamas members will not participate in those talks.
The Egyptians will be the go-between for the sides and will help coordinate, a senior State Department official said, speaking on condition of anonymity because the official wasn't allowed to discuss the issue publicly.
UN spokesman Stephane Dujarric said the cease-fire announcement was the result of Secretary-General Ban Ki-moon's recent trip to the region "but also 48 hours of extremely active diplomacy at all levels from the secretary-general to his senior advisers talking to key regional players."
Robert Serry, the UN special coordinator for the Middle East peace process, U.S. Mideast envoy Frank Lowenstein and others were expected to go to Cairo for the Egyptian-mediated talks.
At least 1,441 Palestinians have been killed, three-quarters of them civilians, since hostilities began on July 8, according to Gaza health ministry officials — surpassing the at least 1,410 Palestinians killed in Israel's last major invasion in 2009, according to Palestinian rights groups.
Israel says 56 soldiers, two Israeli civilians and a Thai agricultural worker have died — far more than the 13 Israeli deaths in the previous campaign.