Having Trouble Sleeping? Israeli Researchers Discover Tiredness Mechanism

An Israeli team of researchers has discovered a mechanism that leads to tiredness in the nervous system of the zebrafish, with supportive evidence for the existence of such a mechanism in mice. Remember the name: Parp1

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An imaging of a zebrafish used in the research. The team caused deliberate damage to the DNA of zebrafish, for example by activating their nerve cells, to see how this affects their sleep.
An imaging of a zebrafish used in the research. The team caused deliberate damage to the DNA of zebrafish, for example by activating their nerve cells, to see how this affects their sleep.
Gid'on Lev
Gid'on Lev

Tiredness, more than hunger, thirst, or pain, may just be the most difficult condition for a human to bear. In his classic short story “Sleepy,” Anton Chekhov describes the loss of humanity caused by deep fatigue: “And Varka is sleepy. Her eyes are glued together, her head droops, her neck aches. She cannot move her eyelids or her lips, and she feels as though her face is dried and wooden, as though her head has become as small as the head of a pin” (translation by Constance Garnett).

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