Safadi was speaking at a news conference following talks with his Russian counterpart Sergei Lavrov in Moscow. After artillery strikes hit Jordanian territory from Syria, he said Jordan's armed forces were ready to defend country's interests.
Safadi told Russia on Wednesday that political dialogue and a ceasefire were priorities for southern Syria where he said a humanitarian catastrophe risked unfolding.
Safadi made the comment after holding talks with his Russian counterpart Sergei Lavrov in Moscow.
He said the situation in southern Syria was a cause for serious concern and needed to be resolved as soon as possible.
The Russian-backed Syrian government has mounted a campaign to recover southwestern Syria from rebels.
Syrian rebel negotiators began a new round of talks with Russian officers on Tuesday over a peace deal in southern Syria under which they would hand over weapons and allow Russian military police to enter rebel-held towns.
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