The Iraqi air force used F-16 jets to cross into Syria and carry out the strikes, Brigadier General Yahya Rasool said.
"The strikes against [ISIS] gangs in the Syrian territory is due to the threat these gangs pose to Iraqi territory, and demonstrates the increased capabilities of our valiant armed forces in pursuing and eliminating terrorism," read a tweet on Iraqi Prime Minister Haider Abadi's office account.
It added that these strikes "will accelerate the elimination" of Islamic State's presence in the region.
Earlier this month, Abadi had said Iraq would "take all necessary measures if they threaten the security of Iraq", referring to the jihadist militants who just three years ago overran a third of Iraq.
The prime minister declared final victory over the ultra hardline group in December but it still poses a threat from pockets along the border with Syria and has continued to carry out ambushes, assassinations and bombings across Iraq.
DPA contributed to this report.