Iran's top authority Supreme Leader Ayatollah Ali Khamenei said on Wednesday Iran would not walk out of a multinational nuclear deal and welcomed backing given by its European signatories.
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Calling the United States an agent of international Zionism and the creator of ISIS, Khamenei said the U.S. is angry because Tehran disrupted Washington's plans in Lebanon, Syria and Iraq, state TV reported.
But he warned that if the U.S. tore up the deal ,"Iran will shred it", referring to a threat by U.S. President Donald Trump.
He also said Tehran would not accept pressure from European countries over its regional policy and missile program, state TV reported.
"European's interference in Iran's missile programme and our regional policy ... the Europeans' following of America's bullying policy is not acceptable for Iran," Khamenei said.
Also on Wednesday, Iran's military chief discussed ways to deepen cooperation with the Syrian military during a visit to Damascus on Wednesday, pledging to fight Israel and Sunni insurgents, Syrian state media said.
"It is not acceptable for the Zionist regime to violate Syria anytime it wants," Baqeri said during a visit to Damascus, according to the Islamic Republic News Agency.
"We are in Damascus to assert and coordinate and cooperate to confront our common enemies, the Zionists and terrorists," Iranian General Mohammad Baqeri said, referring to Israel and Sunni militants including Islamic State. "We drew up the broad lines for this cooperation."
On Tuesday Prime Minister Benjamin Netanyahu told Russia's defense minister that Israel would not allow Iran to increase its influence in Syria.