The U.S. military presence in the Middle East is at its "weakest in history", a deputy commander of Iran's elite Revolutionary Guards was on Sunday quoted by the semi-official news agency Fars as saying.
U.S. President Donald Trump has tightened economic sanctions against Iran, and his administration says it has built up the U.S. military presence in the region.
It accuses Iran of threats to U.S. troops and interests. Tehran has described U.S. moves as "psychological warfare" and a "political game".
"The Americans have been present in the region since 1833 and they are now at their weakest in history in West Asia," said Rear Admiral Ali Fadavi, a deputy Guards commander, according to Fars.
Iran will defend itself against any military or economic aggression, Foreign Minister Mohammad Javad Zarif said on Sunday, calling on European states to do more to preserve a nuclear agreement his country signed.
Speaking in a news conference in Baghdad with his Iraqi counterpart Mohammed al-Hakim, Zarif said his country wanted to build balanced relations with its Gulf Arab neighbours and that it had proposed signing a non-aggression pact with them.
"We will defend against any war efforts against Iran, whether it be an economic war or a military one, and we will face these efforts with strength," he said.
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Strains have increased between Iran and the United States, which is a firm backer of Tehran's regional rival Saudi Arabia, after this month's attack on oil tankers in the Gulf region that Washington has blamed on Iran.
Tehran has distanced itself from the bombings, but the United States has sent an aircraft carrier and an extra 1,500 troops to the Gulf, sparking concerns about the risks of conflict in a volatile region.
Iraq stands with Iran and is willing to act as an intermediary between its neighbour and the United States, Hakim said, adding that Baghdad does not believe an "economic blockade" is fruitful, a reference to U.S. sanctions.
"We are saying very clearly and honestly that we oppose the unilateral actions taken by the United States. We stand with the Islamic Republic of Iran in its position," said Hakim. The United States and Iran are Iraq's two main allies.