No problem with the United States can be resolved and negotiations are a loss, Iran's Supreme Leader Ayatollah Ali Khamenei said on Wednesday in a statement published on his official website.
"With regard to America, no problem can be resolved and negotiations with it has nothing but economic and spiritual loss," he wrote.
Khamenei also said in the statement that the Iranian people now see a number of European governments as untrustworthy.
A U.S. backed international Middle East conference in Poland, set to start on Wednesday, excludes Iran and was slammed by Iran’s Foreign Minister Mohammad Javad Zarif an "anti-Iran circus."
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Speaking of the conference in January, U.S. Secretary of State Pompeo said parties will "work on many issues including how it is we can get the Islamic Republic of Iran to behave more like a normal nation.”