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A Defense Ministry statement reported by the state news agency Tass said the incident occurred Friday east of the ancient city of Palmyra.
According to the statement, the two Russians were making a test flight in the Homs region with a Syrian Mi-25 helicopter that was carrying ammunition. It said ISIS fighters broke through Syrian forces' lines east of Palmyra at the same time.
The statement said the Syrians requested the crew help strike the ISIS fighters and the helicopter was shot down after the crew exhausted its ammunition and it was leaving the scene.