Obama noted that this will be the seventh year that he holds a Seder at the White House, joining "millions of Jewish families as we retell one of humanity’s great stories of liberation."
Obama offered "warm greetings" to Jews celebrating the holiday and spoke of the inspirational nature of the Exodus story.
The statement was released a day after the president had a difficult telephone conversation with Prime Minister Benjamin Netanyahu about a framework nuclear deal reached between the six world powers and Iran.
Netanyahu reiterated during the conversation that "a deal based on this framework will threaten Israel's existence." For his part, Obama said the framework represents significant progress towards a lasting, comprehensive solution that cuts off all of Iran’s pathways to a bomb.
"The Exodus reminds us that progress has always come slow and the future has always been uncertain, but it also reminds there is always reason for hope," Obama said in his Passover greeting.
"Like the Israelites who Moses led out of slavery long ago, it is up to us to never lose faith in the better day that lies ahead."