The Syrian Observatory for Human Rights is reporting that 15 people were killed and injured in an Israeli strike Wednesday in southern Syria, the third such strike in nearly 10 days.
Israel struck targets in southern Syria, state TV reported as military defectors said the missiles targeted Iranian revolutionary guard bases.
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A military spokesman said missiles flying over the Golan Heights targeted several locations and air defences downed several missiles. Live coverage showed a multi-storey building on fire.
"Our air defences responded to an aerial Israeli aggression ... on some targets in the southern region," state media quoted a Syrian army spokesman as saying.
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Two military defectors said the strikes hit the Kisswa area in the southern outskirts of the capital Damascus and military bases used by Lebanon's pro-Iranian Hezbollah group.
There was no immediate comment from an Israeli military spokesman but IDF Chief of Staff Lt. Gen. Aviv Kochavi said last month the missile strikes had "slowed down Iran's entrenchment in Syria".
"We have struck over 500 targets this year, on all fronts, in addition to multiple clandestine missions," Kochavi said in comments published in Israeli media.
The bases in eastern, central and southern Syria which Israel had hit in recent months are believed to have a strong presence of Iranian-backed militias, according to intelligence sources and military defectors familiar with the locations.
Western intelligence sources say Israel's stepped up strikes on Syria in the last few months are part of a shadow war approved by the United States and part of the anti-Iran policy that has undermined in the last two years Iran's extensive military power without triggering a major increase in hostilities.
They say that the past year has seen an expansion in the targets hit by Israel across Syria where thousands of Iranian-backed militias have been involved in regaining much of the territory lost by Syrian President Bashar Assad to insurgents in a nearly decade old civil war.