Arsenal opened up a five-point lead at the top of the Premier League table on Saturday, beating Liverpool 2-0 as Chelsea went down 2-0 at Newcastle United.
Santi Cazorla fired Arsenal into a 19th-minute lead, volleying in the rebound after his initial header from Bacary Sagna's cross had come back off the post. Aaron Ramsey added a second with a ferocious dipping shot just before the hour.
Newcastle's opener came midway through the second half as Yoan Gouffran headed in Yohan Cabaye's free-kick. And in the final seconds, Lois Remy converted Vurnon Anita's delivery to make it 2-0.
"I didn't like the performance and I think we deserved to lose," said Chelsea boss Jose Mourinho.
Under-pressure Fulham manager Martin Jol moved nearer the exit as his side were beaten 3-1 at home by Manchester United. Antonio Valencia gave United the lead from Wayne Rooney's assist after seven minutes, Adnan Januzaj laid on the second for Robin van Persie after 20 minutes and Rooney knocked in a third two minutes later to prompt chants of "Jol Out" from the home fans.
Alex Kacaniklic pulled one back with an effort that went in off Rooney.
United's Manchester rivals City also enjoyed a comprehensive victory, beating struggling Norwich City 7-0. They left out goalkeeper Joe Hart for Costel Pantilimon but the Romania keeper had little to do. A Sergio Aguero shot deflected in off Bradley Johnson after 16 minutes and David Silva added a second four minutes later after fine hold-up play from Aguero.
Five minutes after that Russell Martin put through his own goal and Aguero laid in Alvaro Negredo for a fourth before half-time. Yaya Toure curled in a free-kick to make it five and Aguero added a sixth before Edin Dzeko rounded off the scoring.
Southampton slipped back a place as they were held to a 1-1 draw by Stoke City. Southampton had conceded only three goals so far this season but were behind in bizarre circumstances after 12 seconds, goalkeeper Asmir Begovic's long clearance bouncing over Artur Boruc to give Stoke a 1-0 lead. Jay Rodriguez levelled from Adam Ward-Prowse's floated cross in the final minute of the first half.
The Sunderland recovery hinted at by last week's victory over Newcastle came to an abrupt end with a shambolic 1-0 defeat at Hull City. Yannick Sagbo's effort deflected in off Carlos Cuellar - the third own goal Sunderland have conceded this season and then, in first-half injury-time Lee Cattermole and Andrea Dossena were both sent off for bad challenges.
Crystal Palace remains bottom after a 2-0 defeat at West Bromwich Albion. West Ham United drew 0-0 with Aston Villa.