Israel launched two missiles targeting an empty building in southern Damascus from the Golan Heights, Syrian state TV said early on Wednesday.
It said one of the missiles was shot down and there were no casualties. There was no immediate confirmation from Israel on the strike.
Israel has carried out hundreds of airstrikes inside Syria in the course of the country’s civil war, targeting what it says are suspected arms shipments believed to be bound for Lebanon’s Iran-backed Hezbollah militant group, which is fighting alongside Syrian government forces. It rarely acknowledges or discusses such operations.
Syria announced last week that Israel attacked Homs. According to reports in Syria, Israel struck targets near the Syrian cities of Homs and Tartus on Monday, wounding two soldiers and causing material damage, Syrian state media reported.
"Hostile targets" were intercepted over Homs, SANA initially said, while defense systems were also activated in the port city of Tartus.
The Syrian military said in a statement that the attack came from north of Beirut and that air defenses managed to shoot down most of the missiles used.
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Five people were reportedly killed in late October in a rare daytime missile strike outside Damascus, according to a Syrian rights watchdog. The attack was attributed by Syrian state media to Israel.
The strike targeted a shipment of weapons intended for Hezbollah and making its way to Lebanon, the British-based Syrian Observatory for Human Rights said.
Syrian state media initially reported that the strikes wounded two soldiers and caused material damage, but that air defenses managed to intercept some, but not all, of the surface-to-surface missiles.