Syrian state television reported Wednesday night that Israel had attacked targets south of Quneitra.
According to the report, Syria's air defenses responded to "an Israeli aggression" over the country's southern region. The Israeli military declined to comment.
The state news agency cited a military source saying that there were no casualties and that losses were limited to material damages.
The Britain-based Syrian Observatory for Human Rights said the strikes targeted a military post for government troops and allied Iranian militias in rural Quneitra province in southern Syria on the edge of the Israeli-occupied Golan Heights. The war monitor said the strikes caused loud explosions.
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In January, Syrian media reported intense Israeli strikes in eastern Syria, believed to be among the most intense in nearly a decade.
A Syrian opposition war monitoring group reported at least 18 strikes in Deir el-Zour and along the border with Iraq, saying several arms depots were hit. The Britain-based Syrian Observatory for Human Rights said 57 people were killed, including 14 Syrian troops, and the rest were Iran-backed fighters including 16 Iraqis and 11 Afghans. Dozens were wounded.
The Observatory said it recorded 39 Israeli strikes inside Syria in 2020 that hit 135 targets, including military posts, warehouses or vehicles.
Earlier on Wednesday, the Israeli military spokesman said that an anti-aircraft missile was launched from Lebanon at an Israel Air Force drone, but missed the target.
Two Lebanese security sources said Lebanon's Hezbollah militant group fired at the drone. One of the sources said the missile did not hit the aircraft, which then returned across the border.
Witnesses said they heard the sound of an explosion. Local channel NBN had said earlier that a drone blew up.
Iran-backed Hezbollah, which has a dominant presence in the south near the border, has vowed to bring down Israeli drones breaching Lebanese airspace. The two neighboring enemies last fought in the Second Lebanon War in 2006.