More Than 40 Killed in Gaza’s Deadliest Night in Latest Flare-up; Death Toll in Israel Climbs to 10

At least 42 people were killed in an Israeli airstrike overnight Saturday, making it the deadliest night in the Gaza Strip since the latest round of hostilities between Israel and Hamas began last week.

The deaths, according to Gaza authorities, include 10 children and 16 women. The Palesitinian Health Ministry added more than 50 people were wounded, and rescue efforts are still underway.

The Israeli strikes just after midnight hit a busy street in downtown Gaza City, destroyed two adjacent buildings and one about 50 yards (meters) down the road.

Two doctors, who worked in the nearby Shifa Hospital in northern Gaza – Dr. Moayin Alalol and Dr. Ayman Abu Alouf – were also killed, including seven of Abu Alouf's family members, three of whom were children aged 11, 12 and 16.

According to the latest figures by the Palestinian Health Ministry, at least 188 Palestinians were killed in Israeli strikes since Monday, including 55 children. About 1,200 Palestinians were wounded.

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In Israel, the death toll in attacks from Gaza climbed to 10, including two children.

Nine of those killed in Israel were civilians. In Gaza, the Health Ministry also said most of the casulaties were civilian.

The Israeli military said it destroyed the home of Gaza’s top Hamas leader, Yahya Sinwar, in a separate Saturday strike in the southern Gaza town of Khan Yunis.

It was the third such attack in the last two days on the homes of senior Hamas leaders, who have gone underground.

A 51-year-old Israeli man was killed after a barrage of rocket fire targeted Tel Aviv and central Israel, shattering two days of relative calm in the region. Buildings and infrastructure have been damaged in several cities in central Israel and the IDF downed a media tower housing offices of Al Jazeera, The Associated Press, and other media outlets.

Fighting between Israel and Hamas escalated in what has become the heaviest flare-up since the 2014 Gaza war. Hamas and Islamic Jihad have fired some 3,000 rockets at Israel, according to the IDF, and in response, the military has targeted hundreds of Hamas assets in Gaza.