A single blast was heard Tuesday night in the Israeli town of Sderot near the country's border with the Gaza Strip.
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Israel Defense Forces units were searching the area to locate where rockets fired by militants in Gaza may have fallen.
Sirens were sounded to warn residents to stay off the streets.
The explosion in Sderot comes after a terror cell in Sinai fired a rocket Monday night toward the southern resort city of Eilat. Israel's Iron Dome anti-missile system intercepted the rocket in mid-air.
Defense Minister Moshe Ya'alon warned more attacks could be expected from Sinai militants, but said there was no reason for residents or tourists to be on high alert or alter their daily routines, as an Iron Dome battery has been placed in the area precisely for that reason.