Thirteen clubs at the group stage have already secured their place in the knockout stage, while the final 21 spots will be determined tonight and tomorrow.
In addition to either Hapoel Tel Aviv or Mlada Boleslav advancing after tonight's match, another important Group G contest has Paris St. Germain hosting Panathinaikos.
While the Greek side has assured itself a spot in the next stage, PSG needs a victory tonight to advance to the next level.
Security is expected to be extremely tight at Parc de Princes, the site of a melee following Hapoel's victory over the Parisian club in which one PSG fan was killed by a plainclothes policeman.
French soccer officials called on PSG's fans, who are barred from sitting in the controversial Boulogne section, as well as police, to exhibit restraint.
UEFA has demanded that the club step up security for the game, while the association's spokesman expressed optimism by saying: "There are no problems between the Greek and French fans, and I hope the game passes peacefully."
Rapid Bucharest, which has finished its Group G play, will advance if PSG does not win, regardless of the Hapoel-Mlada outcome.
Tonight's play, which involves Groups E through H, features a number of noteworthy games including the Group E contest between Feyenoord and Wisla Krakow in Rotterdam.
Feyenoord, which was fined 125,000 euro and forced to play games before no home crowd due to fan misbehavior during its match at Nancy two weeks ago, needs a win to advance. Any other result will knock out the Dutch club, which won the UEFA Cup in 2002.
In Group H, four clubs will be battling it out for the two remaining spots in the next stage.
With Newcastle United already having clinched the group's top spot, Celta de Vigo needs just a draw against Palermo to advance, while the Italians need a win.
And in the other group's match, Fenerbahce will advance if it draws against visitors Eintracht Frankfurt, while the German team needs a win.
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