Image made from Syrian State TV video purports to show Syrian troops in Damascus, July 18, 2012.
This image made from Syrian State TV video purports to show Syrian troops fighting against Syrian rebels in the Al-Midan area of Damascus, Syria on Wednesday, July 18, 2012. Photo by AP
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Mystery surrounded the whereabouts of Syrian President Bashar Assad on Thursday, as battles raged in the center of Damascus a day after a bomber killed his top security chiefs.

The Syrian leader made no public appearance and no statement after a bomb in the heart of the capital killed his powerful brother-in-law, his defense minister and a top general, drawing fierce army retaliation with heavy artillery against the rebels.

On Thursday morning, residents said there was no let-up in the heaviest fighting to hit the city in a 16-month revolt against Assad's rule, now into its fifth day.

The fighting came within sight of the presidential palace, near the security headquarters where the bomber struck a crisis meeting of defense and security chiefs.

Residents in the Midan and Kafr Souseh districts said they heard explosions and heavy gunfire as helicopters buzzed overhead.

Checkpoints around Midan and the ancient walled Old City of Damascus had been removed, they said. It was unclear if security forces had changed tactics to prevent rebels from targeting soldiers, or if it was a temporary move in the heat of battle.

On Wednesday, an explosion which nearly no residents heard struck at the heart of Assad's government. Following the attack, rebellious neighborhoods were plunged into fierce battles.

Assad's brother-in-law Assef Shawkat, a top commander and one of the pillars of the Assad clan's rule, was killed in the Wednesday blast along with Defense Minister Daoud Rajha.

Another senior general was also killed and the heads of intelligence and the Interior Ministry were wounded, deeply damaging the security apparatus of the Assad family, which has ruled the country with an iron fist for four decades.

The army shelled its own capital from the surrounding mountains as night fell on Wednesday. Government troops, having vowed retaliation for the assassination, fired machine guns into the city from helicopters.

Rebels, massed in several neighborhoods, are armed mostly with small arms and rocket-propelled grenades.

Activist videos posted on the Internet showed bloodied bodies lying in the street.

Local media, citing security sources, said Assad was still in the capital but gave no further details.

Speaking during a tour of Israel's border with Syria, Defense Minister Ehud Barak said on Thursday that sounds of fighting between Assad's military and rebel forces could be heard in the Golan Heights.

"Less than a kilometer away, maybe a little more, we can actually see the fighting, the mortar bombs, hear the bullets echoing in the fighting between the Syrian army and rebel or opposition groups," Barak said, saying the fighting is uninterrupted, despite the fact that it has been taking place near a UN post and the border fence.

Referring to Wednesday's deadly bombing attack, which killed three of Syria's top security officials, Barak said that the attack demonstrated how "the undoing [of the Assad regime] isn't abstract, it's real, it's getting closer, and what happened yesterday in Damascus will greatly accelerate the fall of the Assad family."

A security source said the bomber who struck inside the security headquarters was a bodyguard for Assad's inner circle. Anti-Assad groups claimed responsibility.

UN Secretary-General Ban Ki-moon condemned the Damascus blast and expressed grave concern over the use of heavy weapons.

"Time is of the essence," he said. "The Syrian people have suffered for too long. The bloodshed must end now."

The UN Security Council put off a scheduled vote on a Syria resolution until Thursday and US President Barack Obama telephoned President Vladimir Putin of Russia, Assad's main ally, to try to persuade Moscow to drop support for him.

Western leaders fear the conflict, which has been joined by al Qaeda-style jihadists, could destabilize Syria's neighbors: Israel, Lebanon, Turkey, Iraq and Jordan.

US Defense Secretary Leon Panetta said: "This is a situation that is rapidly spinning out of control." He called for maximum global pressure on Assad to step down.

Russian Foreign Minister Sergei Lavrov said "the decisive fight" was under way in Damascus.

British Prime Minister David Cameron, whose government has sponsored the sanctions resolution, said on Thursday it was time for Assad to go to avoid an all-out civil war.

The generals killed and wounded in the bombing form the core of Assad's crisis unit to crush the revolt, which grew out of protests inspired by Arab Spring uprisings that unseated leaders in Tunisia, Egypt and Libya.

The armed forces chief of staff, Fahad Jassim al-Freij, quickly took over as defense minister, avoiding any impression of official paralysis.

"This cowardly terrorist act will not deter our men in the armed forces from continuing their sacred mission of pursuing the remnants of these armed terrorist criminal gangs," Freij said on state television. "They will cut off every hand that tries to hurt the security of the nation or its citizens."

The bombing appeared to be part of a coordinated assault on the capital that has escalated since the start of the week. Rebel fighters call it the "liberation of Damascus" after months of fierce clashes which activists say have killed 17,000 people.

Neighboring Jordan's King Abdullah said violence may have ruled out the possibility of a negotiated power transition.

"The realities on the ground may have overtaken us, therefore I think the clock is ticking and we have... reached the point where the political option is too late," he told CNN in an interview.

Rebels were jubilant at their success in penetrating into the capital. Abdullah al-Shami, a rebel commander based in Turkey, said: "I expect a speedy collapse of the regime ... and it means we will not be in need of outside intervention, with the regime beginning to crumble much faster than we envisaged."

Yet some opposition figures said victory would still not be easy.

"It is going to be difficult to sustain supply lines and the rebels may have to make a tactical withdrawal at one point, like they did in other cities," veteran opposition activist Fawaz Tello said from Istanbul.

"But what is clear is that Damascus has joined the revolt."