Iran is earning billions with sales of oil, gas, and petro products, whereas the US economy is on critical life support. Most probabely nobody will care a lot about US sanctions while dealing with Iran. In the end, the sanctions will do more damage to the US economy than to Iran. Regarding 'regime change' in Iran: Oren is delusional, if he thinks a rochade at the helm of Iran would change anything for Israel.
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Iraqi police fire tear gas as thousands of protests burst into Green Zone, storm Parliament (AP)
from the article: Envoy Oren: Iran-Israel relations could change if regime falls