It surely would have been impossible for a document to mean anything if Israel were not singled out in the Middle East. It is the only country there with nuclear weapons, and the only ME country not to sign the NPT. The main effect of Israel's nukes is to cause other countries to want them in defence- notably Iran. Give them up and that excuse goes. The deterrence factor is minimal, unless Israel uses them and is willing to be universally despised for generations. Post Nagasaki/ Hiroshima, there is no place for such weapons.
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Kerry says getting closer to an understanding on renewing Syria ceasefire (Reuters)
from the article: Obama 'strongly' opposes singling out of Israel at nuclear conference