Israel and the US probably cooperated under the Bush administration on regime change in Iran. There are a number of online articles from reputable sources, UK News, of Bush seeking regime change in Iran. Iraq was the first campaign for Bush and Iran was next . Bush hoped to have major bases in Iraq to protect US. interest in the area. Spies were a necessary part of the effort. So Iran had reason to believe Israel and the US were working against Iran.
Yemen's Houthi rebels commit to peace plan in letter to UN chief, BBC reports (Haaretz)
from the article: Iranian 'Mossad agent': I was trained in Israel