One factor to consider is the rapid movement toward pan Islam and pan Arabism. The United States has crippled its image already by invading Afghanistan and Iraq. Can Israeli pressure on American politicians make it happen? Of course. Is it a long term solution, or even smart? No. There is no possibility of a regime in Iran that will be friendly in the foreseeable future. The next step, unfortunately, is much closer cooperation among all Muslim countries, Shia, Sunni whatever. Israel should be playing defense, not offense.
Shaffir to Herzog: Opposition failed to show leadership in political battles against PM (Haaretz)
from the article: Iranian activist says regime change could resolve nuclear standoff