Genetic mutations are found in all human populations the world over. Jews, non Jews, people of different races and nationalities alike. Robust genetic variation between individuals usually means that most genetic mutations are rarely represented in a particular population, although there are lots of mutations out there. Just when certain insular communities go through a restricted population bottleneck, which in other words means that a population in question has at some stage in history was restricted to a a relatively small number of people, if mutations were present in this population at the time, then they get passed onto the larger community over following generations, and pass on their genes- both good and bad onto this community This is essentially been the cause of BrcaI over-representation in some Jewish Ashkenazim communities.
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