You neglect to mention that we (the US) have lived for many years with nuclear armed opponents, and there is no reason we can't do that with Iran. From your viewpoint it would be difficult if Israel were no longer able to use nuclear blackmail on its neighbors. However, with adjustments, you can live with MAD; we have.
Law expanding definition of terrorist activity passes first Knesset reading (Haaretz)
from the article: U.S. warns Iran: Meet nuclear obligations or face 'next step'