One Palestinian man was killed and four others wounded in an explosion at the home of a militant leader in the Gaza Strip on Saturday, Palestinian medics said.

Hamas security officials say the house belongs to Zuhair Qaisi, the chief commander of the Popular Resistance Committees.

The PRC confirmed the man killed was a member of the Popular Resistance Committees and that he was preparing an attack on Israelis when the blast occurred. Zuhair Qaissi himself was not hurt in the explosion.

Bilal Mohammed, 29, a neighbor who witnessed the blast, said a huge explosion and then a string of secondary blasts shook the neighborhood. Flames could be seen rising out of the windows as ambulances rushed to the scene.

Qaissi's predecessor, Kamal Nairab was killed in an Israeli air strike in August.

The Israeli military says it was not involved in the incident.

Two weeks ago, Israeli aircrafts struck a Palestinian rocket-launching squad in the Gaza Strip, amid a string a violent incident along Israel's border with the coastal enclave. One man was killed in the incident and five were wounded. The wounded were reportedly farmers working nearby. It has been quiet along the Israel-Gaza border since.